In this paper, we use evidence from our earlier review of surgical randomised controlled trials with a placebo arm to show that blinding in trials of interventional procedures is feasible.We give examples of ingenious strategies that have been used to simulate the active procedure and to make the Womens Sweater placebo control indistinguishable fro
Dynamics of the Drosophila circadian clock: theoretical anti-jitter network and controlled chaos.
BACKGROUND: Electronic clocks exhibit undesirable jitter or time variations in periodic signals.The circadian clocks of humans, some animals, and plants consist of oscillating molecular networks with peak-to-peak time of approximately 24 hours.Clockwork orange (CWO) is a transcriptional Tack room repressor of Drosophila direct target genes.METHODOL
Correlation between classification and secondary screw penetration in proximal humeral fractures.
In this study, we investigated the correlation between fracture classification and secondary screw penetration.We retrospectively identified 189 patients with displaced proximal humeral fractures treated by ORIF at our hospital between June 2006 and June 2013.All fractures were classified radiographically before surgery and follow-up for least 2 ye
How do eubacterial organisms manage aggregation-prone proteome? [v1; ref status: indexed, http://f1000r.es/3k3]
Eubacterial genomes vary considerably in their nucleotide composition.The percentage of genetic material constituted by guanosine and cytosine (GC) nucleotides ranges from 20% to 70%.It has been posited that GC-poor organisms are more dependent on protein folding machinery.Previous studies have ascribed this to the accumulation of mildly deleteriou